Clustal download

A full description of the algorithms used by Clustal Omega is available in the Molecular Systems Biology paper Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega.

Clustal Omega can be run online at the following websites this list will expand in the coming months. Please that webservers may have limitations on maximum alignment size not present in the standalone version. This release is intended for use with UNIX systems. Installation on Macs is also possible. Windows users should download the binary release below. UNIX and Mac users should rename the downloaded file to clustalo and place in the location of their choice.

This file may need to be made executable e. A Clustal Omega package is available for Gentoo Linux. A SlackBuilds package is also available for Slackware. A Debian package is available as part of Debian Med. We constructed two benchmark data-sets by blending existing structural alignment reference data-sets with homologous unaligned Pfam sequences.

Once you have installed Clustal Omega, type clustalo --help at a command prompt to see a brief overview of all options. The core functions of Clustal Omega are contained in a UNIX library libclustalo which can be used directly by other programs.

The API for using libclustalo is automatically generated using Doxygen. Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega. Molecular Systems Biology doi Clustal W and Clustal X version 2.

Bioinformatics , 23, Multiple sequence alignment with the Clustal series of programs. Nucleic Acids Res. Multiple sequence alignment with Clustal X. Trends Biochem Sci. Methods Enzymol. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Higgins DG.

Methods Mol Biol. Fast and sensitive multiple sequence alignments on a microcomputer. Gene , 73, You can reach us at If you want to report a bug please make sure, that you are using the most recent version of Clustal.

Please also check if the bug has already been reported on our Bugzilla webpage Known issues 2. Postscript output If a Postscript output file contains many sequences, Clustal will shrink the font size in an attempt to fit them all on one page.

This may cause the sequences to be unreadable.